Guided Optimization of a Crystallization-Induced Diastereomer Transformation to Access a Key Navoximod Intermediate
نویسندگان
چکیده
The crystallization-induced diastereomer transformation of a precursor to navoximod was investigated using online HPLC and optimized with inline racemization.
منابع مشابه
Crystallization-induced diastereomer transformation of 2-quinolone-4-carboxamide followed by stereoselective intermolecular photocycloaddition reaction.
2-Quinolone-4-carboxamide derived from (S)-proline, which exists as a mixture of two diastereomers before crystallization, converged to a single diastereomer by crystallization (CIDT), and the homochirality was transferred by a intermolecular 2 + 2 photocycloaddition reaction with high optical activity.
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ژورنال
عنوان ژورنال: Reaction Chemistry and Engineering
سال: 2023
ISSN: ['2058-9883']
DOI: https://doi.org/10.1039/d3re00077j